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Magano J., Dunetz J. — Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies from the Pharmaceutical Industry
Magano J., Dunetz J. — Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies from the Pharmaceutical Industry

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Название: Transition Metal-Catalyzed Couplings in Process Chemistry: Case Studies from the Pharmaceutical Industry

Авторы: Magano J., Dunetz J.

Аннотация:

This one-stop reference source is the first on this new and exciting technology to focus on case studies of large-scale industrial applications, presenting the information and facts that are otherwise hard to find in the current literature.
Authors from Pfizer, Merck, DSM, Novartis, Amgen, and Astra Zeneca, among others, use case studies to showcase project evolution from inception to early and late development, including commercial routes where applicable. Each case study details at least one transition metal-catalyzed cross-coupling step, with special emphasis on lessons learned from their implementation. The important issue of metal removal from the reaction mixtures to meet specifications and the different technologies available to accomplish this goal are also addressed. Finally, a small section covers novel technologies for cross-coupling with high future potential for applications on a large scale, such as metal removal on large scale, microwave and flow chemistry, as well as green chemistry.
Of great interest to chemists working in the pharmaceutical, agrochemical and fine chemical industries, but also for every synthetic chemist working in academia.



Язык: en

Рубрика: Разное/

Статус предметного указателя: Неизвестно

ed2k: ed2k stats

Год издания: 2013

Количество страниц: 401

Добавлена в каталог: 03.06.2017

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