Multiscale Simulations and Mechanics of Biological Materials

 A compilation of recent developments in multiscale simulation and computational biomaterials written by leading specialists in the field

Presenting the latest developments in multiscale mechanics and multiscale simulations, and offering a unique viewpoint on multiscale modelling of biological materials, this book outlines the latest developments in computational biological materials from atomistic and molecular scale simulation on DNA, proteins, and nano-particles, to meoscale soft matter modelling of cells, and to macroscale soft tissue and blood vessel, and bone simulations. Traditionally, computational biomaterials researchers come from biological chemistry and biomedical engineering, so this is probably the first edited book to present work from these talented computational mechanics researchers. 

The book has been written to honor Professor Wing Liu of Northwestern University, USA, who has made pioneering contributions in multiscale simulation and computational biomaterial in specific simulation of drag delivery at atomistic and molecular scale and computational cardiovascular fluid mechanics via immersed finite element method.

Key features:

• Offers a unique interdisciplinary approach to multiscale biomaterial modelling aimed at both accessible introductory and advanced levels
• Presents a breadth of computational approaches for modelling biological materials across multiple length scales (molecular to whole-tissue scale), including solid and fluid based approaches 
• A companion website for supplementary materials plus links to contributors’ websites (www.wiley.com/go/li/multiscale)

Content:
Chapter 1 Atomistic?to?Continuum Coupling Methods for Heat Transfer in Solids (pages 3–20): Gregory J. Wagner
Chapter 2 Accurate Boundary Treatments for Concurrent Multiscale Simulations (pages 21–42): Shaoqiang Tang
Chapter 3 A Multiscale Crystal Defect Dynamics and Its Applications (pages 43–58): Lisheng Liu and Shaofan Li
Chapter 4 Application of Many?Realization Molecular Dynamics Method to Understand the Physics of Nonequilibrium Processes in Solids (pages 59–76): Yao Fu and Albert C. To
Chapter 5 Multiscale, Multiphysics Modeling of Electromechanical Coupling in Surface?Dominated Nanostructures (pages 77–98): Harold S. Park and Michel Devel
Chapter 6 Towards a General Purpose Design System for Composites (pages 99–115): Jacob Fish
Chapter 7 Patient?Specific Computational Fluid Mechanics of Cerebral Arteries with Aneurysm and Stent (pages 119–147): Kenji Takizawa, Kathleen Schjodt, Anthony Puntel, Nikolay Kostov and Tayfun E. Tezduyar
Chapter 8 Application of Isogeometric Analysis to Simulate Local Nanoparticulate Drug Delivery in Patient?Specific Coronary Arteries (pages 149–167): Shaolie S. Hossain and Yongjie Zhang
Chapter 9 Modeling and Rapid Simulation of High?Frequency Scattering Responses of Cellular Groups (pages 169–191): Tarek Ismail Zohdi
Chapter 10 Electrohydrodynamic Assembly of Nanoparticles for Nanoengineered Biosensors (pages 193–206): Jae?Hyun Chung, Hyun?Boo Lee and Jong?Hoon Kim
Chapter 11 Advancements in the Immersed Finite?Element Method and Bio?Medical Applications (pages 207–218): Lucy Zhang, Xingshi Wang and Chu Wang
Chapter 12 Immersed Methods for Compressible Fluid–Solid Interactions (pages 219–237): Xiaodong Sheldon Wang
Chapter 13 The Role of the Cortical Membrane in Cell Mechanics: Model and Simulation (pages 241–265): Louis Foucard, Xavier Espinet, Eduard Benet and Franck J. Vernerey
Chapter 14 Role of Elastin in Arterial Mechanics (pages 267–281): Yanhang Zhang and Shahrokh Zeinali?Davarani
Chapter 15 Characterization of Mechanical Properties of Biological Tissue: Application to the FEM Analysis of the Urinary Bladder (pages 283–300): Eugenio Onate, Facundo J. Bellomo, Virginia Monteiro, Sergio Oller and Liz G. Nallim
Chapter 16 Structure Design of Vascular Stents (pages 301–317): Yaling Liu, Jie Yang, Yihua Zhou and Jia Hu
Chapter 17 Applications of Meshfree Methods in Explicit Fracture and Medical Modeling (pages 319–331): Daniel C. Simkins
Chapter 18 Design of Dynamic and Fatigue?Strength?Enhanced Orthopedic Implants (pages 333–350): Sagar Bhamare, Seetha Ramaiah Mannava, Leonora Felon, David Kirschman, Vijay Vasudevan and Dong Qian
Chapter 19 Archetype Blending Continuum Theory and Compact Bone Mechanics (pages 253–376): Khalil I. Elkhodary, Michael Steven Greene and Devin O'Connor
Chapter 20 Image?Based Multiscale Modeling of Porous Bone Materials (pages 377–401): Judy P. Yang, Sheng?Wei Chi and Jiun?Shyan Chen
Chapter 21 Modeling Nonlinear Plasticity of Bone Mineral from Nanoindentation Data (pages 403–409): Amir Reza Zamiri and Suvranu De
Chapter 22 Mechanics of Cellular Materials and its Applications (pages 411–434): Ji Hoon Kim, Daeyong Kim and Myoung?Gyu Lee
Chapter 23 Biomechanics of Mineralized Collagens (pages 435–447): Ashfaq Adnan, Farzad Sarker and Sheikh F. Ferdous