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Liang P., Meade J., Pardee A. — Differential Display Methods and Protocols
Liang P., Meade J., Pardee A. — Differential Display Methods and Protocols

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Название: Differential Display Methods and Protocols

Авторы: Liang P., Meade J., Pardee A.


Since the first edition of this book dedicated to differential display (DD)
technology was published in 1997, we have witnessed an explosive interest in
studying differential gene expression. The gene-hunting euphoria was initially
powered by the invention of DD, which was gradually overtaken by DNA
microarray technology in recent years. Then why is there still the need for
second edition of this DD book? First of all, DD still enjoys a substantial lead
over DNA microarrays in the ISI citation data (see Table 1), despite the hun￾dreds of millions of dollars spent each year on arrays. This may come as a
surprise to many, but to us it implies that many of the DNA microarray studies
went unpublished owing to their unfulfilled promises (1). Second, unlike DNA
microarrays, DD is an “open”-ended gene discovery method that does not
depend on prior genome sequence information of the organism being studied.
As such, DD is applicable to the study of all living organisms—from bacteria,
fungi, insects, fish, plants, to mammals—even when their genomes are not
sequenced. Second, DD is more accessible technically and financially to most
cost-conscious “cottage-industry” academic laboratories. So clearly DD still
has its unique place in the modern molecular biological toolbox for gene
expression analysis.

Язык: en

Рубрика: Разное/

Статус предметного указателя: Неизвестно

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Год издания: 2006

Количество страниц: 320

Добавлена в каталог: 11.03.2017

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