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Krishnaswamy G., Chi D. — Mast Cells Methods and Protocols
Krishnaswamy G., Chi D. — Mast Cells Methods and Protocols

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Название: Mast Cells Methods and Protocols

Авторы: Krishnaswamy G., Chi D.

Аннотация:

Mast cells are multifunctional, tissue-dwelling cells consisting of two well￾described subsets, MCT and MCTC cells. They are distinguished on the basis of
their tissue location, T-lymphocyte dependence, and ability to synthesize gran￾ule contents such as tryptase and chymase. Following activation, these cells
express mediators, such as histamine, leukotrienes, and prostanoids, proteases,
and various cytokines and chemokines, all of which are pivotal to the genesis
of an inflammatory response. By their interaction with endothelium, macroph￾ages, fibroblasts, and B and T cells, mast cells further amplify the inflamma￾tory cascade. Mast cells directly interact with bacteria and appear to play a
vital role in host defense against pathogens. Additionally, recent data suggests
that mast cells may play an active role in such diverse diseases as asthma,
pulmonary fibrosis, atherosclerosis, malignancy, and arthritis. As research in
mast cells has expanded exponentially, a technical procedure manual for work￾ing with these cells is timely. Thus, the aim of Mast Cells: Methods and Proto￾cols is to present selected molecular and cellular techniques used in studying
various aspects of this fascinating, multifunctional cell.


Язык: en

Рубрика: Разное/

Статус предметного указателя: Неизвестно

ed2k: ed2k stats

Год издания: 2006

Количество страниц: 458

Добавлена в каталог: 26.02.2017

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