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Название: Mast Cells Methods and Protocols
Авторы: Krishnaswamy G., Chi D.
Mast cells are multifunctional, tissue-dwelling cells consisting of two welldescribed subsets, MCT and MCTC cells. They are distinguished on the basis of
their tissue location, T-lymphocyte dependence, and ability to synthesize granule contents such as tryptase and chymase. Following activation, these cells
express mediators, such as histamine, leukotrienes, and prostanoids, proteases,
and various cytokines and chemokines, all of which are pivotal to the genesis
of an inflammatory response. By their interaction with endothelium, macrophages, fibroblasts, and B and T cells, mast cells further amplify the inflammatory cascade. Mast cells directly interact with bacteria and appear to play a
vital role in host defense against pathogens. Additionally, recent data suggests
that mast cells may play an active role in such diverse diseases as asthma,
pulmonary fibrosis, atherosclerosis, malignancy, and arthritis. As research in
mast cells has expanded exponentially, a technical procedure manual for working with these cells is timely. Thus, the aim of Mast Cells: Methods and Protocols is to present selected molecular and cellular techniques used in studying
various aspects of this fascinating, multifunctional cell.