This book constitutes the refereed proceedings of the International Conference on Spatial Cognition, Spatial Cognition 2010, held in Mt. Hood/Portland, OR, USA, in August 2010. The 25 revised full papers presented together with the abstracts of 3 invited papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on distance and time, navigation, science education and spatial skill, language, computational modelling, reference frames, visual attention in spatial reasoning, maps and assistance, as well as language, neuroscience and education.