This book constitutes the refereed proceedings of the 15th International Conference on Information Processing in Medical Imaging, IPMI'97, held in Poultney, Vermont, USA, in June 1997. The 27 revised full papers presented were selected from a total of 96 submissions; also included are 31 poster presentations. The book is divided into topical sections on shape models and matching, novel imaging methods, segmentation, image quality and statistical character of measured data, registration/mapping, statistical models in functional neuroimaging, and MR analysis and processing.