This book constitutes the refereed proceedings of the 6th International Workshop on Next Generation Information Technologies and Systems, NGITS 2006, held in Kibbutz Shefayim, Israel in July 2006.

The 28 revised full papers and 4 revised short papers presented together with 3 invited papers were carefully reviewed and selected from 138 submissions. The papers are organized in topical sections on information integration, next generations applications, information systems development, security and privacy, semi structured data, frameworks, models and taxonomies, simulation and incremental computing, distributed systems, user oriented design, and data mining and agent oriented computing.