Amphetamine-type stimulants are drugs that excite or speed up the central nervous system. ATS use can result in a range of immediate and long-term harm to individuals and is exacting a great toll on families and communities around the world. The present Guide is aimed at policymakers in the field of drug abuse prevention. As such, it concentrates on providing essential information on the reasons why it is crucial to work to prevent ATS abuse and the most important principles to do so effectively.