This book constitutes the refereed proceedings of the 28th International Conference on Computer Safety, Reliability, and Security, SAFECOMP 2008, held in Hamburg, Germany, in September 2009. The 25 full papers presented together with two invited talks were carefully reviewed and selected from 72 submissions. The papers are organized in topical sections on medical systems, industrial experience, security risk analysis, safety guidelines, automotive, aerospace, verification, valdidation, test, fault tolerance, dependability.