A collection of invited talks and oral contributions presented by the leading scientists in their fields, summarizing the progress of, and new prospects for, nuclear physics research. The papers constitute the proceedings of the International Conference on Nuclear Physics at Border Lines. They cover a broad range of developments in nuclear physics: reactions between massive nuclei leading to superheavy element formation; radioactive beams and neutron-rich systems; exotic nuclei and nuclear astrophysics; and new states of nuclear matter.