This volume is dedicated to the memory of the 1996 Turing Award winner Amir Pnueli, who passed away in November 2009. The Festschrift contains 15 scientific articles written by leading scientists who were close to Amir Pnueli either as former students, colleagues or friends. The topics covered span the entire breadth of the scientific work of Amir Pnueli, with a focus on the development and the application of formal methods. Also included is the first chapter of the unpublished Volume III of Zohar Manna and Amir Pnueli’s work on the verification of reactive systems using temporal logic techniques.