This book presents extended and revised versions of the best papers that were presented during the twelfth edition of the IFIP TC10 Working Group 10.5 International Conference on Very Large Scale Integration. The purpose of this conference was to provide a forum to exchange ideas and show research results in the field of microelectronics design. The current trend toward increasing chip integration brings about exhilarating new challenges both at the physical and system-design levels. This book aims to address these exciting issues.