Contents
Preface
Library Synthesis and Quality Control
Using a Noncovalent Protection Strategy to Enhance Solid-Phase Synthesis
Quality Control of Solid-Phase Synthesis by Mass Spectrometry
Preparation of Encoded Combinatorial Libraries for Drug Discovery
Simple Tools for Manual Parallel Solid Phase Synthesis
Cleavage of Compounds from Solid Phase by Gaseous Reagents
Synthesis of DNA-Binding Polyamides: Robust Solid-Phase Methods for Coupling Heterocyclic Aromatic Amino Acids
The Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker
Host-Guest Chemistry: Combinatorial Receptors
Automated Structure Verification of Small Molecules Libraries Using 1D and 2D NMR Techniques
Rapid Liquid-Phase Combinatorial Synthesis of Heterocyclic Libraries
Soluble Polymer-Supported Methods for Combinatorial and Organic Synthesis
Analytical Methods for Optimization and Quality Control of Combinatorial Synthesis
Library Purification and Screening
Resolving Racemic Mixtures Using Parallel Combinatorial Libraries
Ligand Libraries for the Extraction of Metal Ions: Dynamic Combinatorial and High-Throughput Screening Methods
Automated Liquid-Liquid Extraction and Ion-Exchange Solid-Phase Extraction for Initial Purification
On-Bead and Solution Screening Approaches for Genomically Derived Targets: Discovery of Surrogate Ligands and Substrates Using Combinatorial Chemistry Libraries
Computational Library Design
Design of Virtual Combinatorial Libraries
Approaches to Library Design for Combinatorial Chemistry
Reagent-Based and Product-Based Computational Strategies in Library Design
Designing Combinatorial Libraries for Efficient Screening
Application of Neural Networks to Large Dataset QSAR, Virtual Screening, and Library Design
Index