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Авторы: Catron D.J., Zlotnik A.
Lymphotactin is the only member of the С or γ class of chemokines due to the absence of two of the characteristic four cysteines normally found in the chemokine superfamily. In humans, there are two forms, called XCL1 and XCL2, which are the products of two closely related genes. Lymphotactin is found on chromosome 1 in both humans and mice. Lymphotactin is a potent T and NK cell chemoat-tractant. It is a major product of CD8+ T cells, with NKT cells and NK cells, TH 1 CD4+ T cells, mast cells, and 76 T cells also producing it to a lesser degree. Lymphotactin is produced upon T or NK cell activation. Its production can be induced in vitro by T cell mitogens and in vivo during the course of an antigen-specific immune response. IL-10 inhibits its production indirectly by acting on the antigen-presenting cells. The lymphotactin receptor is XCR1 (formerly known as GPR5).