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Название: IL-3 Receptor
Автор: Schrader J.W.
The receptor for IL-3 is made up of two subunits, both members of the cytokine receptor superfamily. The smaller subunit has a low affinity for IL-3 and the complex of IL-3 and the subunit binds to the subunit to form a high-affinity signaling complex. The subunit is shared with the receptors for GM-CSF and IL-5, hence its name, common (c), and alone, has no affinity for any of these three cytokines. In the mouse, however, there is an additional, IL-3- specific subunit, which is encoded by a duplication of the c gene and which has itself a low affinity for IL-3. Signaling downstream of the receptor complex involves activation of JAK2 kinase, tyrosine phosphorylation of c and the initiation of signaling paths regulating growth, survival, and differentiation.