The refereed proceedings of the 10th International Symposium on Spatial and Temporal Databases, SSTD 2007, held in Boston, MA, USA in July 2007. The 26 revised full papers were thoroughly reviewed and selected from a total of 76 submissions. The papers are classified in the following categories, each corresponding to a conference session: continuous monitoring, indexing and query processing, mining, aggregation and interpolation, semantics and modeling, privacy, uncertainty and approximation, streaming data, distributed systems, and spatial networks