Eotaxin 2 is a CC chemokine that appears to bind exclusively to the chemokine receptor CCR3. As expected, eotaxin 2 acts on cells expressing the CCR3 receptor, including eosinophils (Sabroe et aL, 1998). basophils (Uguccioni et aL. 1997). TH2 T cells (Gerber et aL, 1997). and certain subsets of dendritic cells (Sato et aL, 1999) to promote chemotaxis. shape change, and inflammatory mediator production. Eotaxin 2 is therefore of particular interest to researchers studying allergy.