This book constitutes the refereed proceedings of the 6th International Workshop on Databases in Networked Information Systems, DNIS 2010, held in Aizu-Wakamatsu, Japan in October 2010. The 13 revised full papers presented together with 9 invited talks and 1 keynote lecture were carefully reviewed and selected for inclusion in the book. The workshop generally puts the main focus on data semantics and infrastructure for information management and interchange. The papers are organized in topical sections on networked information systems: infrastructure, access to information resources, information and knowledge management systems, information extraction from data resources, and geo-spatial decision making.