This book elucidates how the so-called problem of inference, long a matter of debate among philosophers of logic, epistemology, language, and other domains of speculation, is inextricably tied to the issue of how, in the classical idiom, Knowing is of Being. Motivating this project is an underlying question that guides the discussion throughout: namely, How is it most rational to orient ourselves in thinking about the way that the inferential intelligence articulates the actual? The principal task of the essay as a whole is to think-through this metaphysical question by addressing the Reason (Vernunft) of the act of inference critically and from an onto-epistemological standpoint.