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Youn B.-S., Kwon B.S. — CKB8-1
Youn B.-S., Kwon B.S. — CKB8-1



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Название: CKB8-1

Авторы: Youn B.-S., Kwon B.S.

Аннотация:

cDNA for two new members of the human CC chemokine family was isolated based on structural
and functional similarities to leukotactin 1 (Lkn-1). One of these cDNA clones was identical to the previously isolated CC chemokine, CK 8 (MPIF1), whereas the other is a major splicing variant, therefore named CK 8-1. The mature proteins of CK 8-1 and CK 8 consisted of 116 and 99 amino acids with calculated molecular weights of 12,500 and 10,950, respectively. Both CK 8-1 and CK 8 were potent agonists for CCR1. These chemokines induced migration of neutrophils, monocytes, and lymphocytes, which is similar to Lkn-1. They also significantly suppressed colony formation by human bone marrow, granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. Lkn-1 and CK 8-1 gene were mapped to the same bacterial artificial chromosome. To our knowledge, this is the first example showing that an alternative splicing produces two active CC chemokines from a single gene.


Язык: en

Рубрика: Биология/

Тип: Статья

Статус предметного указателя: Неизвестно

ed2k: ed2k stats

Год издания: 2000

Количество страниц: 6

Добавлена в каталог: 20.11.2006

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