Главная    Ex Libris    Книги    Журналы    Статьи    Серии    Каталог    Wanted    Загрузка    ХудЛит    Справка    Поиск по индексам    Поиск    Форум   

Поиск по указателям

Ember J.A., Hugli T.E. — СЗа Receptor
Ember J.A., Hugli T.E. — СЗа Receptor

Читать книгу

Скачать книгу с нашего сайта нельзя

Обсудите книгу на научном форуме

Нашли опечатку?
Выделите ее мышкой и нажмите Ctrl+Enter

Название: СЗа Receptor

Авторы: Ember J.A., Hugli T.E.


СЗа receptor (C3aR) is a G prolein-coupled receptor oi the rhodopsin superfamily. The receptor contains the characteristic seven transmembrane domains connected by intra- and extracellular loops, with the N-lerminus having an extracellular orientation and the C-terminus being intracellular and the region to which the G proteins bind. C3aR has a major distinguishing feature, which is an extraordinarily large extracellular loop between the fourth and fifth transmembrane helices. This loop in human C3aR contains 175 residues: in most G protein-coupled receptors the corresponding extracellular loop region is 30-40 residues in length.
The C3aR is widely distributed in both myeloid cells and nonmyeloid tissue cells. The C3aR on eosinophils and basophils is thought to be particularly important biologically since these cells are che-motactically activated by the ligand C3a. Neutrophils also express C3aR. but the ligand can only induce calcium mobilization in these cells and does not cause granular release, oxygen radical generation, or chemotaxis. C3aR expression has been shown to be upregulated on astrocytes and other brain cells during inflammation. Only one form of C3aR has been detected in human, rat. and mouse, but two isoforms of C3aR have been described in the guinea pig (C3aR-S and C3aR-L for small and large forms).

Язык: en

Рубрика: Биология/

Тип: Статья

Статус предметного указателя: Неизвестно

ed2k: ed2k stats

Год издания: 2000

Количество страниц: 9

Добавлена в каталог: 19.11.2006

Операции: Положить на полку | Скопировать ссылку для форума | Скопировать ID
Предметный указатель
       © Электронная библиотека попечительского совета мехмата МГУ, 2004-2019
Электронная библиотека мехмата МГУ | Valid HTML 4.01! | Valid CSS! О проекте