This practical collection provides a comprehensive update on clinically relevant in vitro and in vivo models of thrombosis and hemostasis for the discovery and testing of antithrombotics, and summarizes recent development in pharmaceuticals for the prevention and treatment of various thromboembolic disorders. Topics of the 17 contributions include low molecular weight heparins, antithrombotic drugs for the treatment of heparin-induced thrombocytopenia, guidelines for the diagnosis of deep venous thrombosis and pulmonary embolism, the development of both small and large animal models, the characteristics of factor Xa inhibitors, and the development of therapeutic candidates based on cell adhesion molecules.