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Название: The Orexin Hypocretin System: Physiology and Pathophysiology
Авторы: Nishino S., Sakurai T.
Orexin/hypocretin research began in 1998, as a result of the discovery of a newhypothalamic neuropeptide. In 1999, it was found that mutations in the orexin/hypocretin-related genes caused a sleep disorder (narcolepsy) in dogs and mice.These findings were soon followed by the discoveries of orexin/hypocretin liganddeficiency in human narcolepsy.