The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose mem-bers are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.The National Research Council (NRC) is the operating arm of the National Academies, which includes the National Academy of Sciences,the National Academy of Engineering, and the Institute of Medicine. The National Research Council was organized in 1916 by the NationalAcademy of Sciences to associate the broad community of science and technology with the Academy's purposes of furthering knowledge andproviding impartial advice to the federal government.