"This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers." — Jacket. Sequence databases / Rolf Apweiler — Mapping databases / Tara Matise and Peter S. White — Information retrieval from biological databases / Andreas D. Baxevanis — Genomic databases / Tyra Wolfsberg — Predictive methods using DNA sequences / Roderic Guigo? and Enrique Blanco — Predictive methods using RNA sequences / Michael Zucker and David Mathews — Sequence polymorphisms / James C. Mullikin and Stephen T. Sherry — Predictive methods using protein sequences / Burkhard Rost and Yanay Ofran — Protein structure prediction and analysis / David Wishart — Intermolecular interactions and biological pathways / Gary D. Bader and Anton J. Enright — Assessing pairwise sequence similarity: blast and fasta / Andreas D. Baxevanis — Creation and analysis of protein multiple sequence alignments / Geoffrey J. Barton — Sequence assembly and finishing methods / Gerard Bouffard, Nancy F. Hansen, and Pamela Jacques Thomas — Phylogenetic analysis / Fiona S.L. Brinkman — Computational approaches in comparative genomics / Andreas D. Baxevanis — Microarray analysis / John Quackenbush — Proteomics and protein identification / Michael Giddings, Mark R. Holmes, and Kevin Ramkissoon — Using perl to facilitate biological analysis / Lincoln D. Stein