In the course of our individual research programs, we have had occasion to utilize hetero Diels-Alder reactions as pivotal steps in natural product total syntheses. It became clear to us during the early stages of our work that this type of cycloaddition, although a potentially powerful synthetic tool, had found relatively little general use. Moreover, it was also evident that reviews on various aspects of this chemistry were often out-of-date or nonexistent. In response to this situation, we have written several journal reviews on different facets of hetero Diels-Alder methodology during the past few years. With an apparent increase in the appreciation of the value of [4 + 21 cycloadditions in heterocyclic synthesis, we felt it was appropriate to write this monograph.
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