This volume constitutes the proceedings of the 6th International Conference on Database and Expert Systems Applications, DEXA '95, held in London, UK in September 1995. The 60 full revised papers presented in the volume were carefully selected from a total of almost 200 submissions and give a comprehensive view over advanced applications of information systems. Among the topics covered are object-oriented databases, advanced database applications, parallel and distributed systems, object-oriented modeling, information retrieval, theoretical aspects, extended relational databases, expert and knowledge-based systems, and physical aspects.