This book constitutes the refereed proceedings of the 14th International Conference on Artificial Intelligence: Methodology, Systems, and Applications, AIMSA 2010, held in Varna, Bulgaria in September 2010.The 26 revised full papers presented together with the 13 posters were carefully reviewed and selected from 93 submissions. The papers are organized in topical sections on knowledge representation and reasoning; intelligent techniques for adaption, personalization, and recommendation; constraints and search; machine learning, data mining, and information retrieval; AI in education; applications.