This book constitutes the refereed proceedings of the 10th European Conference on Evolutionary Computation in Combinatorial Optimization, EvoCOP 2010, held in Instanbul, Turkey, in April 2010. The 24 revised full papers presented were carefully reviewed an selected from 69 submissions. The papers present the latest research and discuss current developments and applications in metaheuristics - a paradigm to effectively solve difficult combinatorial optimization problems appearing in various industrial, economical, and scientific domains. Prominent examples of metaheuristics are evolutionary algorithms, simulated annealing, tabu search, scatter search, memetic algorithms, variable neighborhood search, iterated local search, greedy radomized adaptive search procedures, estimation of distribution algorithms and ant colony opitmization.