This book constitutes the refereed proceedings of the 12th International Conference on Coordination Models and Languages, COORDINATION 2010, held in Amsterdam, The Netherlands, in June 2010, as one of the federated conferences on Distributed Computing Techniques, DisCoTec 2010. The 12 revised full papers presented were carefully reviewed and selected from 28 submissions. The papers cover a wide range of topics including the application of coordination in wireless systems; multicore scheduling; sensor networks; event processing; data flow networks; and railway interlocking.