This book constitutes the refereed proceedings of the International Conference on Web Information Systems and Mining, WISM 2010, held in Sanya, China, on October 23-24, 2010. The 54 revised full papers presented in this volume were carefully reviewed and selected from 603 submissions. The papers are organized in topical sections on applications of web information systems, applications of web mining, distributed systems, e-government and e-commerce, geographic information systems, information security, intelligent networked systems, management information systems, mobile computing, web content mining, web information classification, web information retrieval, web services and e-learning, and XML and semi-structured data.