The books (LNCS 6094 and 6095) constitute the refereed proceedings of the 10th International Conference on Intelligent Tutoring Systems, ITS 2010, held in Pittsburgh, PA, USA, in June 2010. The 61 revised full papers, 5 invited talks, and 58 short papers presented were carefully viewed and selected from 186 submissions. The papers are organized in topical sections on educational data mining, natural language interaction; ITS in Ill-defined domains; inquiry learning, collaborative and group learning; intelligent games; gaming the system; pedagogical strategies; affect; games and augmented reality; pedagogical agents, learning companions, and teachable agents; intelligent tutoring and scaffolding; metacognition; and authoring tools and theoretical synthesis.