This practical book is part of the new Artech House Methods in Bioengineering series volumes designed to offer detailed guidance on authoritative methods for addressing specific bioengineering challenges. Written and edited by recognized experts in the field, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. This volume focuses on the design of state-of-the art methods for investigating complex biological systems and the development of complex models to analyze the data. You find how-to guidance on: Experimental approaches for investigating cellular behavior in health and disease; Algorithms and modeling techniques for quantitatively describing biomedical problems; The integration of experimental and computational approaches for an integrative view of biological systems.