This book constitutes the proceedings of the 15th International Workshop on Formal Methods for Industrial Critical Systems, FMICS 2010 held in Antwerp, Belgium, in September 2010 - co-located with ASE 2010, the 25th IEEE/ACM International Conference on Automated Software Engineering, The 14 papers presented were carefully reviewed and selected from 33 submissions. The aim of the FMICS workshop series is to provide a forum for researchers who are interested in the development and application of formal methods in industry. It also strives to promote research and development for the improvement of formal methods and tools for industrial applications.