This book constitutes the proceedings of the 5th International Conference on Graph Transformations, ICGT 2010, held in Twente, The Netherlands, in September/October 2010. The 22 papers presented were carefully reviewed and selected from 48 submissions. These papers mirror the wide-ranged ongoing research activities in the theory and application of graph transformation. They are concerned with different kinds of graph transformation approaches, their algebraic foundations, composition and analysis, the relation to logic, as well as various applications, mainly to model transformation and distributed systems.