This book constitutes the thoroughly refereed post-proceedings of the 14th International Smalltalk Conference, ISC 2006, held in Prague, Czech Republic in September 2006. The 7 revised full papers presented were carefully reviewed and selected from the technical contributions held during the academic track of the conference. Being a live forum on cutting edge software technologies the conference produced papers - from foundational issues to advanced applications - that attracted researchers and professionals from both academia and industry.