This book constitutes the refereed proceedings of the 5th International Conference: Testing: Academic and Industrial Conference - Practice and Research Techniques, TAIC PART 2010, held in Windsor, UK, in September 2010. The 15 revised full papers presented together with 7 abstracts and 3 keynote addresses were carefully selected from 40 submissions. The papers cover a wide range of topics related to fundamental research questions in the field of software testing and analysis focusing on the practical challenges that are often faced by software developers in industry.