This two-volume proceedings contains revised selected papers from the International Conference on Artificial Intelligence and Computational Intelligence, AICI 2010, held in Sanya, China, in October 2010. The total of 105 high-quality papers presented were carefully reviewed and selected from 1216 submissions. The topics covered are: applications of artificial intelligence; automated problem solving; automatic programming; data mining and knowledge discovering; distributed AI and agents; expert and decision support systems; fuzzy logic and soft computing; intelligent information fusion; intelligent scheduling; intelligent signal processing; machine learning; machine vision; multi-agent systems; natural language processing; neural networks; pattern recognition; robotics; applications of computational intelligence; biomedical informatics and computation; fuzzy computation; genetic algorithms; immune computation; information security; intelligent agents and systems; nature computation; particle swarm optimization; and probabilistic reasoning.