Chapter 1 briefly describes the main properties of space plasmas and primary CR. Chapter 2 considers the problem of CR propagation in space plasmas described by the kinetic equation and different types of diffusion approximations. Chapter 3 is devoted to CR non-linear effects in space plasmas caused by CR pressure and CR kinetic stream instabilities with the generation of Alfv?n turbulence. In Chapter 4 different processes of CR acceleration in space plasmas are considered. The book ends with a list providing more than 1,300 full references, a discussion on future developments and unsolved problems, as well as Object and Author indexes.