This volume contains the Lectures and selected participant contributions to the 14th Course of the International School of Cosmic Rays Astrophysics, a NATO Advanced Study Institute. Well known astrophysicists and astronomers discuss different aspects of the generation of high energy signals in powerful astrophysical objects concentrating on the production of neutrinos and gamma rays from high energy particle interactions. Recent results from new experiments and observatories are presented. Topics cover a wide range including the Spitzer infrared observatory, TeV gamma ray observations, dark matter, and neutrino telescopes. The combination of basic knowledge about the production of high energy signals with information about the data analysis of ongoing observations places the book between the usual levels of a textbook and a conference proceedings. It will give the reader a good introduction to the current field of astroparticle physics, and some of the fascinating astrophysics being addressed.