The first instances of deformation theory were given by Kodaira and Spencer for complex structures and by Gerstenhaber for associative algebras. Since then, deformation theory has been applied as a useful tool in the study of many other mathematical structures, and even today it plays an important role in many developments of modern mathematics. This volume collects a few self-contained and peer-reviewed papers by experts which present up-to-date research topics in algebraic and motivic topology, quantum field theory, algebraic geometry, noncommutative geometry and the deformation theory of Poisson algebras. They originate from activities at the Max-Planck-Institute for Mathematics and the Hausdorff Center for Mathematics in Bonn.