This book constitutes the thoroughly refereed post-proceedings of the Second European AcrossGrid Conference, AxGrids 2004, held in Nicosia, Cyprus in January 2004.

The 27 revised full papers and 4 revised short papers presented were carefully selected during two rounds of reviewing and improvement from 57 submissions. The papers address the entire range of current topics in grid computing from computational and data grids to the semantic grid and grid application in various fields.