The evolution of modern cell biology tools, such as confocal imaging techniques and advanced electron microscopy methodologies, has allowed for ever improving structural and functional characterizations of the cell. Such methods complement classical genetics and biochemistry in the ongoing effort to define cellular science. This is especially apparent in the area of organcllc biology. Studies dating back over 100 years to tbc present have revealed the elaborate collection of distinctive membrane-bound cytoplasmic subcompartments, termed organdies, within the eukaryocic cell and defined their roles in mediating numerous specialized functions in cellular physiology. Organelles play an essential role in the cell in large part through ensuring a right regulatory and functional separation of distinct chemical reactions, such as cellular respiration, and molecular processes, such as protein degradation and DNA replication. Many organelles are common to virtually all cell types (e.g., the nucleus) while others reside only in certain differentiated cells (e.g., the lysosome-related lytic granules and melanosomes found in cytotoxic T lymphocytes and melanocytes, respectively). The unique characteristics of such heterogeneous cellular organelles are dictated by their particular biochemical composition and complement of biomolecules...