This book constitutes the thoroughly refereed post-workshop proceedings of the 22nd International Workshop on Languages and Compilers for Parallel Computing, LCPC 2009, held in Newark, DE, USA, in October 2009. The 25 revised full papers and 5 revised short papers presented were carefully reviewed and selected from 52 submissions. The papers address all aspects of languages, compiler techniques, run-time environments, and compiler-related performance evaluation for parallel and high-performance computing and extend the area of interest to new parallel computing accelerators such as IBM Cell processor and Graphic Processing Unit (GPU) presenting the latest work of leading researchers and practitioners in the field.