Bioinformatics, in this context the application of computer science to biological problems, has become an indispensable part of any research in the biosciences. Rapid developments in gene sequencing, structure determination as well as rational protein engineering and design have made it necessary for biologists, chemists, and computer scientists to channel their expertise into large scale collaborative projects. This GBF Monograph gives a general overview of the latest versatile activities in bioinformatics: * Biological Data Bases * DNA and RNA * Protein Sequences and Structures * From Molecules to Cell Metabolism The articles have been selected from contributions to a conference on Bioinformatics/Computer Application in the Biosciences, held in October 1995 in Braunschweig at the German National Research Center for Biotechnology.