The two volumes LNCS 4688 and LNBI 4689 constitute the refereed proceedings of the International Conference on Life System Modeling and Simulation, LSMS 2007, held in Shanghai, China, in September 2007.

The 147 revised full papers were carefully reviewed and selected from 1383 submissions. The 84 papers of LNCS 4688 are organized in topical sections on advanced neural network theory, algorithms and application, advanced evolutionary computing theory, algorithms and application, ant colonies and particle swarm optimization and application, fuzzy, neural, fuzzy-neuro hybrids and application, intelligent modeling, monitoring, and control of complex nonlinear systems, as well as biomedical signal processing, imaging and visualization.