This book constitutes the refereed proceedings of the International Conference on Advanced Software Engineering and Its Applications, ASEA 2010, held as part of the Future Generation Information Technology Conference, FGIT 2010, in Jeju Island, Korea, in December 2010. The 40 full papers presented were carefully reviewed and selected from 175 submissions. The papers deal with ideas, problems and solutions relating to the multifaceted aspects of software engineering, including its links to computational sciences, mathematics and information technology.