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Название: BioNMR in Drug Research
Авторы: Zerbe O., Mannhold R., Kubinyi H.
Thanks to the vast progress made in the investigation of biomolecules using NMR during the later 1990s, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular. Content: Part I: Basic techniques — Modern methods for the expression of proteins in isotopically enriched form / Heiko Patzelt ... [et al.] — Structure calculation using automated techniques / Peter Gu?ntert — Achieving better sensitivity, less noise and fewer artifacts in NMR spectra / Detlef Moskau and Oliver Zerbe — Part II: NMR of biomolecules — NMR strategies for protein assignments / Volker Do?tsch — NMR of membrane-associated peptides and proteins / Reto Bader, Mirjam Lerch, and Oliver Zerbe — NMR of nucleic acids / Radovan Fiala and Vladimi?r Sklena?r? — Part III: Modern spectroscopic techniques — Methods for the measurement of angle restraints from scalar, dipolar couplings and from cross-correlated relaxation : application to biomacromolecules / Christian Griesinger — Orientational restraints / Eva de Alba and Nico Tjandra — Scalar couplings across hydrogen bonds / Andrew J. Dingley ... [et al.] — TROSY : transverse relaxation-optimized spectroscopy / Roland Riek — MAS solid-state NMR of isotopically enriched biological samples / Philip T.F. Williamson, Matthias Ernst, and Beat H. Meier — Determination of protein dynamics using [superscript 15]N relaxation measurements / David Fushman — Part IV: Tools for investigation of drug-receptor complexes and for ligand screening — The determination of equilibrium dissociation constants of protein-ligand complexes by NMR / Gordon C.K. Roberts — Experiments in NMR-based screening / Carla Marchioro ... [et al.] — The use of spin labels in NMR-supported lead finding and optimization / Wolfgang Jahnke — NMR of weakly binding ligands / Marcel J.J. Blommers and Simon Ru?disser — Isotope filter and editing techniques / Gerd Gemmecker — Part V: Strategies for drug development using NMR — Strategies for NMR screening and library design / Christopher A. Lepre — Strategies for hit finding using NMR / Werner Klaus and Hans Senn. Strategies for drug discovery using NMR / Marcel J.J. Blommers, Andreas Flo?rsheimer, and Wolfgang Jahnke — NMR-based drug design : approaches for very large proteins / Maurizio Pellecchia ... [et al.]. Abstract: Thanks to the vast progress made in the investigation of biomolecules using NMR during the later 1990s, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular