This book constitutes the thoroughly refereed postproceedings of the First International Life Science Grid Workshop, LSGRID 2004, held in Kanazawa, Japan in May/ June 2004.

The 10 revised full papers and 5 invited papers presented were carefully selected and went through two rounds of reviewing and revision. Among the topics addressed are grid environment for bioinformatics, grid architectures, database federation, proteome annotation, grid workflow software, functional genome annotation, protein classification, tree inference, parallel computing, high performance computing, grid infrastructures, functional genomics, and evolutionary algorithms.