This book constitutes the refereed proceedings of the First International Symposium on Medical Data Analysis, ISMDA 2000, held in Frankfurt, Germany in September 2000. The 33 revised papers presented together with four keynote presentations were carefully reviewed and selected from 45 submissions. The book offers topical sections on time series analysis, Bayesian networks, neural network, machine learning, architectures for data acquisition and data analysis, medical informatics and modeling, genetic and fuzzy algorithms, and medical data mining.